Setting up the grid: I will generally start with 0.1 (the pitch of a pin header in Imperial increments) and snap the major component(s) to the grid. i.e. An Uno board would be the headers, then line the Uno board shape reference marks for the headers up with the header part (you may need to zoom in for this) and lock the board... then work down from there with smaller increments (0.05", 0.025"). I will then set the grid at 0.05", place the rest of the components and run the traces. If the traces need to be closer together I will set the grid to 0.025". All traces should be run a 90 and 45 deg. with few exceptions. If a component will not snap so the trace will run parallel, you can turn off the grid and move that component into position.
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