I think this is more operator error than a bug. For starters in schematic R2 is short circuited by the wire running through it which shorts the fet gate to the drain which is neither intended nor correct. Delete that wire and you see that it should connect only to the gate and resistor not the drain as well. That connection will reflect in to both pcb and breadboard views and cause problems.. In PCB view the rats nest view (before routing) connects straight line and can cause the optical illusion of connections where there in fact aren't any. Try manually routing the board before deciding there are shorts as some that appear to be shorts are in probably just rats nest routing fooling you. On a non Fritzing note, I see that the i2c connector is fed with 3.3V implying that the device connected is 3.3V, are the output pins of the Wemos 3.3V or 5V (I see it has both voltages)? If the outputs are in fact 5V you may need a level translator between 5V and 3.3 if the i2c device is indeed 3.3v.
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